浙江大学转化医学研究院是浙大新近成立的以转化医学为研究重点的研究机构，孙毅教授为2013年度国家“千人计划”获得者，担任美国Michigan大学医学院教授，现为转化医学研究院院长。

实验室现因工作需要，面向国内外公开招聘从事肿瘤生物学及相关研究领域的博士后研究人员数名。

具有肿瘤生物学，分子生物学等相关领域的研究背景，熟练掌握目前常规的分子生物学、细胞生物学、动物模型实验技术手段，有较好的英语表达和写作能力，满足浙江大学博士后进站的有关规定。有相关研究经验和较好独立研究能力者请提供证明材料（如导师推荐信等）并优先录用。

享受浙江大学博士后待遇外，视工作表现另提供奖励津贴。转化院和医学院提供完整的研究平台，可开展多样化的转化医学研究工作。

1．个人简历（包括个人学习、科研工作经历及感兴趣研究方向的简要介绍等）；

2．本科、研究生毕业证书和学位证书扫描件一份；

 

 

 

 

Introduction of Prof. Sun’s Lab

The Sun laboratory is focused on understanding the molecular mechanisms involved in regulation of apoptosis, angiogenesis, and radioresistance by SCF E3 ubiquitin ligases and p53 signal pathways with the ultimate aim of identifying and validating targets for mechanism-driven, anti-cancer drug discovery. 

SAG (Sensitive to Apoptosis Gene, also known as RBX2 or ROC2) was cloned in Sun laboratory. SAG forms active E3 ubiquitin ligases of SCF (Skp1, cullin1 and F-box protein) and VCB (VHL-Elongin-C/B) to promote the ubiquitination and degradation of a number of cellular critical proteins, such as p27, caspase-3, HIF-1α, c-Jun, and IkBα, thus regulating proliferation, apoptosis, hypoxia response, and carcinogenesis. SAG is over-expressed in non-small lung cell carcinoma, which correlates with poor prognosis.  Physiological functions of SAG are being studied using constitutive knockout and conditional knockout.

RPS27L, a novel ribosomal like gene, initially identified in Sun laboratory as a p53-inducible gene from an genome profiling experiment. Further characterization of RPS27L revealed that it is a novel p53 target that mediates p53-induced apoptosis through inhibiting Mdm2. Physiological functions of RPS27L are being studied using constitutive knockout and conditional knockout.

We have conducted a siRNA library screening for potential targets whose silencing induces radiosensitization. Among 8,800 “druggable” target genes screened, we identified and confirmed 23 potential candidates and one third of these candidate hits centered in one particular ubiquitin pathway. We are currently conducting the follow-up experiments to elucidate the mechanism of action.