We are looking for a highly motivated MD or PhD graduate, who is interested to work in the field of virus immunology and chronic virus infections. In particular, the innate and adaptive immune system will be analyzed by investigating virus infection in an in vivo and in vitro system. The aim is to understand development of chronic virus infections and develop therapeutic strategies with basic research techniques. The models will focus on murine viruses such as the lymphocytic choriomeningitis virus and the vesicular stomatitis virus. The techniques used will include:
Tissue culture, RT-PCR, PCR, virus Handling and virus techniques, respectful experimental animal handling, flow cytometry.
Detailled information can be found in:
Pellegrini M, Calzascia T, Toe JG, Preston SP, Lin AE, Elford AR, Shahinian A, Lang PA, Lang KS, Morre M, Assouline B, Lahl K, Sparwasser T, Tedder TF, Paik JH, DePinho RA, Basta S, Ohashi PS & Mak TW. IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell 2011; 144:601-613
Lang PA, Recher M, Honke N, Scheu S, Borkens S, Gailus N, Krings C, Meryk A, Kulawik A, Cervantes-Barragan L, Van Rooijen N, Kalinke U, Ludewig B, Hengartner H, Harris N, Haussinger D, Ohashi PS, Zinkernagel RM & Lang KS. Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice. Hepatology 2010; 52:25-32
Lang PA, Cervantes-Barragan L, Verschoor A, Navarini AA, Recher M, Pellegrini M, Flatz L, Bergthaler A, Honda K, Ludewig B, Ohashi PS & Lang KS. Hematopoietic cell-derived interferon controls viral replication and virus-induced disease. Blood 2009; 113:1045-1052
Lang PA, Contaldo C, Georgiev P, El-Badry AM, Recher M, Kurrer M, Cervantes-Barragan L, Ludewig B, Calzascia T, Bolinger B, Merkler D, Odermatt B, Bader M, Graf R, Clavien PA, Hegazy AN, Lohning M, Harris NL, Ohashi PS, Hengartner H, Zinkernagel RM & Lang KS. Aggravation of viral hepatitis by platelet-derived serotonin. Nat Med 2008; 14:756-761
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