How are signaling events transmitted from one protein to another? To answer this question we are looking to add a postdoctoral co-worker to our interdisciplinary team. Our interest is to understand protein-protein interactions, protein structure and dynamics in the context of cell signaling mechanisms. {e.g. see our recent papers J.Biol.Chem. 284, 35962-72 (2009); J.Biol.Chem. 286, 26093-106 (2011); Structure 20, 41-55 (2012)}. The systems include several small GTPases and their interacting proteins, principally the cytoplasmic domains of plexins and of other receptors.

Research in protein biophysics/structural biology. We principally use solution NMR for protein structure determination, surface mapping and characterization of conformational change. The project may involve amide hydrogen exchange, NMR relaxation and molecular dynamics simulation as additional tools. NMR facilities at the Cleveland Center for Structural Biology consist of two 600MHz, an 800MHz and an 900MHz Bruker spectrometers all with cryoprobes. Apart from NMR, we employ other biophysical techniques including circular dichroism and fluorescence spectroscopy as well as isothermal titration calorimetry (ITC). Recently have started x-ray crystallography as a second major component to the laboratory (a Rigaku MicroMax-007 HF instrument with a 94×94mm CCD detector has recently been installed for crystal screening).

We are looking for a talented and highly motivated coworker, who aims to become independent researcher/project leader. Prior experience with protein NMR or x-ray crystallography is essential. The Buck laboratory provides a stimulating but friendly working environment – we are still relatively small & young, which has advantages. The Medical School of Case Western Reserve University is highly rated overall in the US (~ 23rd in terms of NIH funding) and Cleveland is a pleasant but affordable place to live with excellent educational, medical and cultural institutions. Starting date, project details and salary are negotiable. Please send your resume, overview of your scientific interests and career goals as well as contact details of three referees able to provide references by e-mail to Matthias.Buck@case.edu