Employer: Wayne State University School of Medicine 
Website: http://mott.med.wayne.edu/ 
Location: C.S. Mott Center for Human Growth and Development, 275 E. Hancock, Detroit, MI, United States 
Type: Postdoctoral 
Posted: November 29, 2011 
Expires: December 25, 2011 
Requisition number: 112911 
job description 
Several wet-bench and computational postdoctoral positions are immediately available as part of an interdisciplinary research team using advanced high-throughput and analysis strategies using NEXT GENERATION SEQUENCING, Genome aCGH and Expression arrays, Real-Time and Computational technologies to determine how RNA regulates chromatin structure and gene expression in early development. The successful applicants will join the Krawetz group http://compbio.med.wayne.edu will use a systems approach to determine how the delivery of sperm RNAs are essential to early development and their perturbation by environmental exposures modulate the Fetal Origins of Adult Disease.. Self motivated individuals trained in molecular biology, genetics and/or biochemistry, bioinformatics or the reproductive sciences that are able to easily work in the United States are especially encouraged to apply. Applicants should forward their curriculum vitae and three letters of reference to: Professor S. A. Krawetz, C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, 275 E. Hancock, Detroit, MI 48201. E-mail: steve@compbio.med.wayne.edu. WSU is an Equal Opportunity/Affirmative Action Employer.
Sperm RNA Delivery and the Nucleus:
• Ostermeier, G.C., Miller, D., Huntriss, J.D., Diamond, M.P. and Krawetz, S.A. (2004) Delivering spermatozoan RNA to the oocyte. Nature 429:154.
• Krawetz, S.A. (2005) Paternal Contribution: new insights and future challenges. Nature Rev Genetics 6:633-642.
• Platts, A.E., Dix, D. J., Chemes, H.E., Thompson, K.E., Goodrich, R., Rockett, J. C., Rawe, V.Y., Quintana, S., Diamond, M.P., Strader, L.F. and Krawetz, S.A. (2007) 
Success and failure in human spermatogenesis as revealed by teratozoospermic RNAs. Human Molecular Genetics. 16:763-773.
• Johnson, G. D., Lalancette, C., Linnemann, A.K., Leduc, F., Boissonneault, G., Krawetz, S.A. (2011) The sperm nucleus: chromatin, RNA and the nuclear matrix. Reproduction 141 21-36. PMID:20876223
• Johnson, G.D., Sendler, E., Lalancette, C., Hauser, R., Diamond, M.P. and Krawetz, S.A. (2011) Cleavage of rRNA in ensures translational cessation to prepare sperm for fertilization. Molecular Human Reproduction. 17:721-726
• Krawetz, S.A., Kruger, A., Lalancette, C., Tagett, R., Anton, E., Draghici, S. and Diamond, M. (2011) A survey of small RNAs in human sperm. Human Reproduction. 26: 3401-3412
Reprogramming:
• Martins, R. P. and Krawetz, S.A. (2007) Decondensing the protamine domain for transcription. Proceedings of the National Academy of Sciences (U.S.A.) 104:8340-8345.
• Linnemann, A.K., Platts, A.E. and Krawetz, S.A. (2009) Differential Nuclear Scaffold/Matrix Attachment Marks Expressed Genes. Human Molecular Genetics. 18:645-654 (cover feature).
• Arpahahi, A., Brinkworth, M., Iles, D., Krawetz, S.A., Paradowska, A., Platts, A.E., Saida, M., Steger, K., Tedder, P. and Miller, D. (2009) Endonuclease-sensitive regions of human spermatozoal chromatin are highly enriched in promoter and CTCF binding sequences. Genome Research. 191338-1349.
• Johnson, G.D., Platts, A.E., Lalancette, C., Goodrich, R. and Krawetz, S.A. (2011) Interrogating the transgenic genome: Development of an interspecies tiling array. Systems Biology in Reproductive Medicine. 57:54-62
THE WAYNE STATE COMMUNITY
• C.S. Mott Center for Human Growth and Development see http://mott.med.wayne.edu/
• Michigan Alliance for Clinical Translational Research program
• University Cultural Center Association see http://detroitmidtown.com/05/
• Live Midtown see: http://livemidtown.org/
• Wayne State’s “Campus and Community” see: http://wayne.edu/community/