中国科学院上海生命科学研究院生物化学与细胞生物学研究所惠静毅研究组
本研究组主要通过分子生物学、生物化学及生物信息学等方法研究哺乳动物细胞中RNA加工调控的机制与功能。实验室情况介绍请见http://www.sibcb.ac.cn/PI.asp?id=119。

应聘要求：

1.    近期获得生物学或医学专业博士学位；
2.    具有分子生物学和生物化学等相关专业研究背景；
3.    工作认真严谨，有责任心，并具独立工作能力和团队协作精神；
4.    有良好的英语阅读写作及听说交流能力；
5.    曾作为第一作者发表过SCI研究论文者优先考虑。

应聘者请将本人应聘材料，包括求职信、中英文个人简历以及发表论文的PDF文件等用Email发至 jyhui@sibs.ac.cn (邮件标题请注明“博士后应聘”)。符合要求者，将安排面试，薪酬面议。不邀请参加面试者将不一一回复，请见谅。谢绝来电来访。实验室将对申请材料严格保密。

代表性论文：

Heiner M, Jingyi Hui, Schreiner S, Hung LH, Bindereif A. HnRNP L-mediated regulation of mammalian alternative splicing by interference with splice site recognition. RNA Biol. (2010) 7,56-64. Hung L.H.*, Heiner M.*, Hui J.*, Schreiner S., Benes V., and Bindereif A. Diverse roles of hnRNP L in mammalian mRNA processing: a combined microarray and RNAi analysis. RNA. 14, 284-296 (2008). Lorenz M., Hewing B., Hui J., Zepp A., Baumann G., Bindereif A., Stangl V., Stangl K. Alternative splicing in intron 13 of the human eNOS gene: a potential mechanism for regulating eNOS activity. FASEB J. 21, 1556-1564 (2007). Hui J., and Bindereif A. Alternative pre-mRNA splicing in the human system: unexpected role of repetitive sequences as regulatory elements. Biol Chem. 386, 1265-1271 (2005) (an invited review). Hui J.*, Hung L.H.*, Heiner M., Schreiner S., Neumuller N., Reither G., Haas S.A., and Bindereif A. Intronic CA-repeat and CA-rich elements: a new class of regulators of mammalian alternative splicing. EMBO J. 24, 1988-1998 (2005). Palfi Z., Hui J., and Bindereif A. Biotin-based affinity purification of RNA-protein complexes. In Handbook of RNA biochemistry, (Westhof E., Bindereif A., Schön A., and Hartmann R.K., eds.), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, pp676-693 (2004). Hui J., Reither G., and Bindereif A. Novel function role of CA repeats and hnRNP L in RNA stability. RNA. 9, 931-936 (2003). Hui J., Stangl K., Lane W.L., and Bindereif A. HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats. Nat. Struct. Biol. 10, 33-37 (2003). Comment by Bilbao D. and Valcárcel J. Getting to the heart of a splicing enhancer. Nat Struct Biol. 10, 6-7 (2003). Yang J., Hui J., Li G., Wang Y., Yuan H., and Li Y. Expression of the recombinant hepatitis B virus surface antigen carrying preS epitopes in Pichia pastoris. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai), 32, 39-144 (2000). Hui J., Li G., Kong Y., and Wang Y. Expression and characterization of chimeric hepatitis B surface antigen particles carrying preS epitopes. J. Biotechnol. 72, 49-59 (1999). Hui J., Mancini M., Li G., Wang Y., Tiollais P., and Michel M.L. Immunization with a plasmid encoding a modified hepatitis B surface antigen carrying the receptor binding site for hepatocytes. Vaccine, 17, 1711-1718 (1999). Hui J., Li G., Kong Y., and Wang Y. DNA-mediated immunization against hepatitis B surface antigen carrying preS epitopes. Chinese Science Bulletin, 44, 620-623 (1999). Hui J., Li G., Kong Y., and Wang Y. A modified HBsAg containing the preS1 and preS2 epitopes. Science in China, (Series C), 41, 56-63 (1998). (* equal contribution)